What does this mean?

Saffr0n: A "no response from host" or "destination host unreachable" at intermediary hops likely isn't the cause of your lag spikes. You should only be worried if you get an unresponsive ping followed up by nothing else in route to the final hop. This would mean that your connection isn't going through. A "no response from host' or PL on intermediary hops can be caused by the node prioritizing specific packets or purposely dropping them as part of security protocols, either CoPP or DDoS protection.    If you're experiencing lag spikes and unsure where it's coming from, you can post your WinMTR or PingPlotter results in this thread.